Association of mild kidney dysfunction with diastolic dysfunction and heart failure with preserved ejection fraction.

ABSTRACT:

Aims

We aim to investigate the association between kidney dysfunction and left ventricular diastolic dysfunction parameters and heart failure with preserved ejection fraction (HFpEF) and whether this is sex-specific.

Methods and results

We included participants from the HELPFul observational study. Outpatient clinical care data, including echocardiography, and an expert panel judgement on HFpEF was collected. Estimated glomerular filtration rate (eGFR) was calculated by creatinine and cystatin C without race. The association between eGFR with E/e', left ventricular mass index, relative wall thickness, and stage C/D heart failure was tested by multivariable adjusted regression models, stratified by sex, reporting odds ratios and 95% confidence intervals (95% confidence interv

SUBMITTER: Vernooij RWM 

PROVIDER: S-EPMC10804207 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature