Hydralazine combined with conventional therapy improved outcomes in severe systolic dysfunction and mitral regurgitation.

ABSTRACT:

Aims

Patients with heart failure (HF) and reduced left ventricular ejection fraction (LVEF) accompanied by significant mitral regurgitation (MR) had poor outcome. Several vasodilator trials showed neutral results. We aimed to investigate the effect of early up-titration of hydralazine combined with conventional treatment in acute HF with severe systolic dysfunction and significant MR.

Methods and results

The study was open-labelled, one-to-one ratio randomized designed. Consecutively hospitalized patients with decompensated HF symptoms, LVEF < 35%, and MR more than moderate severity were enrolled after exclusion. All participants with inadequate preload should have intake promotion with/without fluid supply. Patients receiving evidence-based medications (EBMs) as conventiona

SUBMITTER: Hsiao SH 

PROVIDER: S-EPMC10804220 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature