B2M is a Biomarker Associated With Immune Infiltration In High Altitude Pulmonary Edema.

ABSTRACT:

Background

High altitude pulmonary edema (HAPE) is a serious mountain sickness with certain mortality. Its early diagnosis is very important. However, the mechanism of its onset and progression is still controversial.

Aim

This study aimed to analyze the HAPE occurrence and development mechanism and search for prospective biomarkers in peripheral blood.

Methods

The difference genes (DEGs) of the Control group and the HAPE group were enriched by gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, and then GSEA analysis was performed. After identifying the immune-related hub genes, QPCR was used to verify and analyze the hub gene function and diagnostic value with single-gene GSEA and ROC curves, and the drugs that acted on the hub gen

SUBMITTER: Yuan M 

PROVIDER: S-EPMC10804239 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature