Antipsychotics and the QTc Interval During Delirium in the Intensive Care Unit: A Secondary Analysis of a Randomized Clinical Trial.

ABSTRACT:

Importance

Antipsychotic medications, often prescribed for delirium in intensive care units (ICUs), may contribute to QTc interval prolongation.

Objective

To determine whether antipsychotics increase the QTc interval in patients with delirium in the ICU.

Design, setting, and participants

An a priori analysis of a randomized clinical trial in medical/surgical ICUs within 16 centers across the US was conducted. Participants included adults with delirium in the ICU with baseline QTc interval less than 550 ms. The study was conducted from December 2011 to August 2017. Data analysis was performed from April 25 to August 18, 2021.

Interventions

Patients were randomized 1:1:1 to intravenous haloperidol, ziprasidone, or saline placebo administered twice daily until res

SUBMITTER: Stollings JL 

PROVIDER: S-EPMC10804270 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature