Cardiovascular, Neurological, and Immunological Adverse Events and the 23-Valent Pneumococcal Polysaccharide Vaccine.

ABSTRACT:

Importance

Despite widespread immunization with the 23-valent pneumococcal polysaccharide vaccine (PPSV23), safety concerns remain owing to a lack of statistical power and largely outdated evidence.

Objective

To evaluate the association between cardiovascular, neurological, and immunological adverse events and PPSV23 vaccination in older adults.

Design, setting, and participants

This population-based cohort study using a self-controlled risk interval design used a large linked database created by linking the Korea Immunization Registry Information System and the National Health Information Database (2018 to 2021). Participants included patients aged 65 years or older with a history of PPSV23 vaccination and incident cardiovascular, neurological, or immunological event

SUBMITTER: Yoon D 

PROVIDER: S-EPMC10804273 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature