Diagnostic Accuracy of a Plasma Phosphorylated Tau 217 Immunoassay for Alzheimer Disease Pathology.

ABSTRACT:

Importance

Phosphorylated tau (p-tau) is a specific blood biomarker for Alzheimer disease (AD) pathology, with p-tau217 considered to have the most utility. However, availability of p-tau217 tests for research and clinical use has been limited. Expanding access to this highly accurate AD biomarker is crucial for wider evaluation and implementation of AD blood tests.

Objective

To determine the utility of a novel and commercially available immunoassay for plasma p-tau217 to detect AD pathology and evaluate reference ranges for abnormal amyloid β (Aβ) and longitudinal change across 3 selected cohorts.

Design, setting, and participants

This cohort study examined data from 3 single-center observational cohorts: cross-sectional and longitudinal data from the Translational B

SUBMITTER: Ashton NJ 

PROVIDER: S-EPMC10804282 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature