Role of the IgG4-related cholangitis autoantigen annexin A11 in cholangiocyte protection.

ABSTRACT:

Background & aims

Annexin A11 was identified as autoantigen in IgG4-related cholangitis (IRC), a B-cell driven disease. Annexin A11 modulates calcium-dependent exocytosis, a crucial mechanism for insertion of proteins into their target membranes. Human cholangiocytes form an apical 'biliary bicarbonate umbrella' regarded as defense against harmful hydrophobic bile acid influx. The bicarbonate secretory machinery comprises the chloride/bicarbonate exchanger AE2 and the chloride channel ANO1. We aimed to investigate the expression and function of annexin A11 in human cholangiocytes and a potential role of IgG1/IgG4-mediated autoreactivity against annexin A11 in the pathogenesis of IRC.

Methods

Expression of annexin A11 in human liver was studied by immunohistochemistry and imm

SUBMITTER: Herta T 

PROVIDER: S-EPMC10804347 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature