An exploration of actigraphy in the context of ketamine and treatment-resistant depression.

ABSTRACT:

Objectives

This study explored the potential of non-parametric and complexity analysis metrics to detect changes in activity post-ketamine and their association with depressive symptomatology.

Methods

Individuals with treatment-resistant depression (TRD: n = 27, 16F, 35.9 ± 10.8 years) and healthy volunteers (HVs: n = 9, 4F, 36.4 ± 9.59 years) had their activity monitored during an inpatient, double-blind, crossover study where they received an infusion of ketamine or saline placebo. All participants were 18-65 years old, medication-free, and had a MADRS score ≥20. Non-parametric metrics averaged over each study day, metrics derived from complexity analysis, and traditionally calculated non-parametric metrics averaged over two weeks were calculated from the actigraphy time s

SUBMITTER: Punturieri C 

PROVIDER: S-EPMC10804352 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature