Effects of andrographolide on intrahepatic cholestasis induced by alpha-naphthylisothiocyanate in rats.

ABSTRACT: Cholestasis is a cardinal manifestation of liver diseases but effective therapeutic approaches are limited. Therefore, alternative therapy for treating and preventing cholestatic liver diseases is necessary. Andrographolide, a promising anticancer drug derived from the medicinal plant Andrographis paniculata, has diverse pharmacological properties and multi-spectrum therapeutic applications. However, it is unknown whether andrographolide has a hepatoprotective effect on intrahepatic cholestasis. The aims of this study were to investigate the protective effect and possible mechanisms of andrographolide in a rat model of acute intrahepatic cholestasis induced by alpha-naphthylisothiocyanate (ANIT). Andrographolide was administered intragastrically for four consecutive days, with a single int

SUBMITTER: Khamphaya T 

PROVIDER: S-EPMC10804355 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature