Clinical Risk Score to Predict Pathogenic Genotypes in Patients With Dilated Cardiomyopathy.

ABSTRACT:

Background

Although genotyping allows family screening and influences risk-stratification in patients with nonischemic dilated cardiomyopathy (DCM) or isolated left ventricular systolic dysfunction (LVSD), its result is negative in a significant number of patients, limiting its widespread adoption.

Objectives

This study sought to develop and externally validate a score that predicts the probability for a positive genetic test result (G+) in DCM/LVSD.

Methods

Clinical, electrocardiogram, and echocardiographic variables were collected in 1,015 genotyped patients from Spain with DCM/LVSD. Multivariable logistic regression analysis was used to identify variables independently predicting G+, which were summed to create the Madrid Genotype Score. The external validation sam

SUBMITTER: Escobar-Lopez L 

PROVIDER: S-EPMC10804447 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature