Anti-rheumatic colchicine phytochemical exhibits potent antiviral activities against avian and seasonal Influenza A viruses (IAVs) via targeting different stages of IAV replication cycle.

ABSTRACT:

Background

The continuous evolution of drug-resistant influenza viruses highlights the necessity for repurposing naturally-derived and safe phytochemicals with anti-influenza activity as novel broad-spectrum anti-influenza medications.

Methods

In this study, nitrogenous alkaloids were tested for their viral inhibitory activity against influenza A/H1N1 and A/H5N1 viruses. The cytotoxicity of tested alkaloids on MDCK showed a high safety range (CC₅₀ > 200 µg/ml), permitting the screening for their anti-influenza potential.

Results

Herein, atropine sulphate, pilocarpine hydrochloride and colchicine displayed anti-H5N1 activities with IC₅₀ values of 2.300, 0.210 and 0.111 µg/ml, respectively. Validation of the IC₅₀ values was further depic

SUBMITTER: Hegazy A 

PROVIDER: S-EPMC10804494 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature