Intestinal microbiota and metabolome perturbations in ischemic and idiopathic dilated cardiomyopathy.

ABSTRACT:

Background

Various clinical similarities are present in ischemic (ICM) and idiopathic dilated cardiomyopathy (IDCM), leading to ambiguity on some occasions. Previous studies have reported that intestinal microbiota appeared dysbiosis in ICM, whether implicating in the IDCM remains unclear. The aim of this study was to assess the alterations in intestinal microbiota and fecal metabolites in ICM and IDCM.

Methods

ICM (n = 20), IDCM (n = 22), and healthy controls (HC, n = 20) were enrolled in this study. Stool samples were collected for 16S rRNA gene sequencing and gas chromatography-mass spectrometry (GC-MS) analysis.

Results

Both ICM and IDCM exhibited reduced alpha diversity and altered microbial community structure compared to HC. At the genus level, nine taxa includ

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10804607 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature