Chromatin accessibility and cell cycle progression are controlled by the HDAC-associated Sin3B protein in murine hematopoietic stem cells.

ABSTRACT:

Background

Blood homeostasis requires the daily production of millions of terminally differentiated effector cells that all originate from hematopoietic stem cells (HSCs). HSCs are rare and exhibit unique self-renewal and multipotent properties, which depend on their ability to maintain quiescence through ill-defined processes. Defective control of cell cycle progression can eventually lead to bone marrow failure or malignancy. In particular, the molecular mechanisms tying cell cycle re-entry to cell fate commitment in HSCs remain elusive. Previous studies have identified chromatin coordination as a key regulator of differentiation in embryonic stem cells.

Results

Here, we utilized genetic inactivation of the chromatin-associated Sin3B protein to manipulate cell cycle contro

SUBMITTER: Calderon A 

PROVIDER: S-EPMC10804615 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature