Subclinical epileptiform activity in the Alzheimer continuum: association with disease, cognition and detection method.

ABSTRACT:

Background

Epileptic seizures are an established comorbidity of Alzheimer's disease (AD). Subclinical epileptiform activity (SEA) as detected by 24-h electroencephalography (EEG) or magneto-encephalography (MEG) has been reported in temporal regions of clinically diagnosed AD patients. Although epileptic activity in AD probably arises in the mesial temporal lobe, electrical activity within this region might not propagate to EEG scalp electrodes and could remain undetected by standard EEG. However, SEA might lead to faster cognitive decline in AD.

Aims

1. To estimate the prevalence of SEA and interictal epileptic discharges (IEDs) in a well-defined cohort of participants belonging to the AD continuum, including preclinical AD subjects, as compared with cognitively healthy con

SUBMITTER: Nous A 

PROVIDER: S-EPMC10804650 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature