Residues within the LptC transmembrane helix are critical for Escherichia coli LptB₂ FG ATPase regulation.

ABSTRACT: Lipopolysaccharide (LPS) synthesis in Gram-negative bacteria is completed at the outer leaflet of the inner membrane (IM). Following synthesis, seven LPS transport (Lpt) proteins facilitate the movement of LPS to the outer membrane (OM), an essential process that if disrupted at any stage has lethal effects on bacterial viability. LptB₂ FG, the IM component of the Lpt bridge system, is a type VI ABC transporter that provides the driving force for LPS extraction from the IM and subsequent transport across a stable protein bridge to the outer leaflet of the OM. LptC is a periplasmic protein anchored to the IM by a single transmembrane (TM) helix intercalating within the lateral gate formed by LptF TM5 and LptG TM1. LptC facilitates the hand-off of LPS from LptB₂ FG to t

SUBMITTER: Cina NP 

PROVIDER: S-EPMC10804673 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature