Cortico-basal ganglia white matter microstructure is linked to restricted repetitive behavior in autism spectrum disorder.

ABSTRACT:

Background

Restricted repetitive behavior (RRB) is one of two behavioral domains required for the diagnosis of autism spectrum disorder (ASD). Neuroimaging is widely used to study brain alterations associated with ASD and the domain of social and communication deficits, but there has been less work regarding brain alterations linked to RRB.

Methods

We utilized neuroimaging data from the National Institute of Mental Health Data Archive to assess basal ganglia and cerebellum structure in a cohort of children and adolescents with ASD compared to typically developing (TD) controls. We evaluated regional gray matter volumes from T1-weighted anatomical scans and assessed diffusion-weighted scans to quantify white matter microstructure with free-water imaging. We also investigated

SUBMITTER: Wilkes BJ 

PROVIDER: S-EPMC10804694 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature