The association between adipokines and pulmonary diseases: a mendelian randomization study.

ABSTRACT:

Background

The role of adipokines in the development of lung diseases is significant, yet their specific relationship with different lung diseases remains unclear.

Methods

In our research, we analyzed genetic variations associated with adipokines and various lung conditions such as interstitial lung disease, chronic obstructive pulmonary disease, asthma, lung cancer, sleep apnea, pneumonia, and tuberculosis, using data from public genome-wide studies. We employed Mendelian randomization techniques, including inverse variance weighting, weighted median, and MR-Egger regression methods, and conducted sensitivity checks to validate our findings.

Results

A study using the FinnGen database, which included 198,955 participants, identified 13 SNPs associated with adiponectin

SUBMITTER: Wu D 

PROVIDER: S-EPMC10804699 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature