Associations between sex, body mass index and the individual microglial response in Alzheimer's disease.

ABSTRACT:

Background and objectives

18-kDa translocator protein position-emission-tomography (TSPO-PET) imaging emerged for in vivo assessment of neuroinflammation in Alzheimer's disease (AD) research. Sex and obesity effects on TSPO-PET binding have been reported for cognitively normal humans (CN), but such effects have not yet been systematically evaluated in patients with AD. Thus, we aimed to investigate the impact of sex and obesity on the relationship between β-amyloid-accumulation and microglial activation in AD.

Methods

49 patients with AD (29 females, all Aβ-positive) and 15 Aβ-negative CN (8 female) underwent TSPO-PET ([¹⁸F]GE-180) and β-amyloid-PET ([¹⁸F]flutemetamol) imaging. In 24 patients with AD (14 females), tau-PET ([¹⁸F]PI-2620) was a

SUBMITTER: Biechele G 

PROVIDER: S-EPMC10804830 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature