CD44-targeting hyaluronic acid-selenium nanoparticles boost functional recovery following spinal cord injury.

ABSTRACT:

Background

Therapeutic strategies based on scavenging reactive oxygen species (ROS) and suppressing inflammatory cascades are effective in improving functional recovery after spinal cord injury (SCI). However, the lack of targeting nanoparticles (NPs) with powerful antioxidant and anti-inflammatory properties hampers the clinical translation of these strategies. Here, CD44-targeting hyaluronic acid-selenium (HA-Se) NPs were designed and prepared for scavenging ROS and suppressing inflammatory responses in the injured spinal cord, enhancing functional recovery.

Results

The HA-Se NPs were easily prepared through direct reduction of seleninic acid in the presence of HA. The obtained HA-Se NPs exhibited a remarkable capacity to eliminate free radicals and CD44 receptor-facilitat

SUBMITTER: Luo W 

PROVIDER: S-EPMC10804833 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature