Lactate-lactylation-HSPA6 axis promotes PRRSV replication by impairing IFN-β production.

ABSTRACT: Lactate, traditionally considered a metabolic by-product, has recently been identified as a substrate for the induction of lactylation, a newly identified epigenetic modification that plays an important role in the regulation of host gene expression. Our previous study showed that lactate levels were significantly elevated in cells infected with the porcine reproductive and respiratory syndrome virus (PRRSV), an Arterivirus that has devastated the swine industry worldwide for over 30 years. However, the role of elevated lactate in PRRSV infections remains unknown. In this study, we found that lactate was required for optimal PRRSV proliferation, and PRRSV infection increased cellular lactylation in a dose-dependent manner. Using the Cleavage Under Targets and Tagmentation (CUT&Tag)

SUBMITTER: Pang Y 

PROVIDER: S-EPMC10804950 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature