Genomic Stratification of Clozapine Prescription Patterns Using Schizophrenia Polygenic Scores.

ABSTRACT:

Background

Treatment-resistant schizophrenia affects approximately 30% of individuals with the disorder. Clozapine is the medication of choice in treatment-resistant schizophrenia, but optimizing administration and dose titration is complex. The identification of factors influencing clozapine prescription and response, including genetics, is of interest in a precision psychiatry framework.

Methods

We used linear regression models accounting for demographic, pharmacological, and clinical covariates to determine whether a polygenic risk score (PRS) for schizophrenia would be associated with the highest dose recorded during clozapine treatment. Analyses were performed across 2 independent multiancestry samples of individuals from a UK patient monitoring system, CLOZUK2 (n = 313

SUBMITTER: Kappel DB 

PROVIDER: S-EPMC10804961 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature