Remodeling of the gastric environment in Helicobacter pylori-induced atrophic gastritis.

ABSTRACT: Helicobacter pylori colonization of the human stomach is a strong risk factor for gastric cancer. To investigate H. pylori-induced gastric molecular alterations, we used a Mongolian gerbil model of gastric carcinogenesis. Histologic evaluation revealed varying levels of atrophic gastritis (a premalignant condition characterized by parietal and chief cell loss) in H. pylori-infected animals, and transcriptional profiling revealed a loss of markers for these cell types. We then assessed the spatial distribution and relative abundance of proteins in the gastric tissues using imaging mass spectrometry and liquid chromatography with tandem mass spectrometry. We detected striking differences in the protein content of corpus and antrum tissues. Four hundred ninety-two protein

SUBMITTER: Shuman JHB 

PROVIDER: S-EPMC10805037 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature