Severity of polycystic kidney disease revealed by multiparametric MRI.

ABSTRACT:

Purpose

We aimed to compare multiple MRI parameters, including relaxation rates ( R1$$ {R}_1 $$ , R2$$ {R}_2 $$ , and R1ρ$$ {R}_{1\rho } $$ ), ADC from diffusion weighted imaging, pool size ratio (PSR) from quantitative magnetization transfer, and measures of exchange from spin-lock imaging ( Sρ$$ {S}_{\rho } $$ ), for assessing and predicting the severity of polycystic kidney disease (PKD) over time.

Methods

Pcy/Pcy mice with CD1 strain, a mouse model of autosomal dominant PKD, were imaged at 5, 9, and 26 wk of age using a 7T MRI system. Twelve-week normal CD1 mice were used as controls. Post-mortem paraffin tissue sections were stained using hematoxylin and eosin and picrosirius red to identify histological changes.

Results

Histology detected segmental cyst formatio

SUBMITTER: Wang F 

PROVIDER: S-EPMC10805116 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature