Tricyclic antipsychotics promote adipogenic gene expression to potentiate preadipocyte differentiation in vitro.

ABSTRACT: Antipsychotic-induced weight gain is a well-established but poorly understood clinical phenomenon. New mechanistic insights into how antipsychotics modulate adipose physiology are sorely needed, in hopes of either devising a therapeutic intervention to ameliorate weight gain or contributing to improved design of future agents. In this study, we have hypothesized that the weight gain-associated tricyclic antipsychotics clozapine and chlorpromazine directly impact adipose tissue by potentiating adipogenic differentiation of preadipocytes. Utilizing a well-established in vitro model system (3T3-L1 preadipocyte cell line), we demonstrate that, when applied specifically during induction of adipogenic differentiation, both clozapine and chlorpromazine significantly potentiate in vitro adipogenes

SUBMITTER: Cottingham CM 

PROVIDER: S-EPMC10805149 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature