A pilot study of fecal pH and redox as functional markers in the premature infant gut microbiome.

ABSTRACT: The infant gut microbiome is a crucial factor in health and development. In preterm infants, altered gut microbiome composition and function have been linked to serious neonatal complications such as necrotizing enterocolitis and sepsis, which can lead to long-term disability. Although many studies have described links between microbiome composition and disease risk, there is a need for biomarkers to identify infants at risk of these complications in practice. In this pilot study, we obtained stool samples from preterm infant participants longitudinally during the first postnatal months, and measured pH and redox, as well as SCFA content and microbiome composition by 16S rRNA gene amplicon sequencing. These outcomes were compared to clinical data to better understand the role of pH and red

SUBMITTER: Letourneau J 

PROVIDER: S-EPMC10805279 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature