Examining B-cell dynamics and responsiveness in different inflammatory milieus using an agent-based model.

ABSTRACT:

Introduction

B-cells are essential components of the immune system that neutralize infectious agents through the generation of antigen-specific antibodies and through the phagocytic functions of naïve and memory B-cells. However, the B-cell response can become compromised by a variety of conditions that alter the overall inflammatory milieu, be that due to substantial, acute insults as seen in sepsis, or due to those that produce low-level, smoldering background inflammation such as diabetes, obesity, or advanced age. This B-cell dysfunction, mediated by the inflammatory cytokines Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-α), increases the susceptibility of late-stage sepsis patients to nosocomial infections and increases the incidence or severity of recurrent infec

SUBMITTER: Shin B 

PROVIDER: S-EPMC10805321 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature