Relationship between inflammatory bowel disease and erectile dysfunction: a 2-sample Mendelian randomization study.

ABSTRACT:

Background

Observational studies have indicated a high prevalence of erectile dysfunction (ED) among patients with inflammatory bowel disease (IBD), but a definitive causal relationship remains unestablished.

Aim

The primary aim of this study was to assess the potential causal relationship between IBD and ED using Mendelian randomization (MR) analysis.

Methods

We obtained statistical data for 2 subtypes of IBD, ulcerative colitis (UC) and Crohn's disease (CD), as well as for ED, from publicly available genome-wide association studies (GWASs). Subsequently, a 2-sample MR analysis was conducted using these datasets. The primary MR analysis utilized the inverse variance-weighted (IVW) method, complemented by secondary analyses employing MR-Egger and weighted median metho

SUBMITTER: Gao D 

PROVIDER: S-EPMC10805346 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature