Signatures of Co-evolution and Co-regulation in the CYP3A and CYP4F Genes in Humans.

ABSTRACT: Cytochromes P450 (CYP450) are hemoproteins generally involved in the detoxification of the body of xenobiotic molecules. They participate in the metabolism of many drugs and genetic polymorphisms in humans have been found to impact drug responses and metabolic functions. In this study, we investigate the genetic diversity of CYP450 genes. We found that two clusters, CYP3A and CYP4F, are notably differentiated across human populations with evidence for selective pressures acting on both clusters: we found signals of recent positive selection in CYP3A and CYP4F genes and signals of balancing selection in CYP4F genes. Furthermore, an extensive amount of unusual linkage disequilibrium is detected in this latter cluster, indicating co-evolution signatures among CYP4F genes. Several of the selec

SUBMITTER: Richard-St-Hilaire A 

PROVIDER: S-EPMC10805436 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature