Inhibition of the interaction between microglial adenosine 2A receptor and NLRP3 inflammasome attenuates neuroinflammation posttraumatic brain injury.

ABSTRACT:

Aims

Adenosine 2A receptor (A_2A R) is widely expressed in the brain and plays important roles in neuroinflammation, and the nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) inflammasome is a crucial component of the innate immune system while the regulation of A_2A R on it in the central nervous system (CNS) has not been clarified.

Methods

The effects of microglial A_2A R on NLRP3 inflammasome assembly and activation were investigated in wild-type, A_2A R- or NLRP3-knockout primary microglia with pharmacological treatment. Microglial A_2A R or NLRP3 conditional knockout mice were used to interrogate the effects of this regulation on neuroinflammation posttraumatic

SUBMITTER: Du H 

PROVIDER: S-EPMC10805470 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature