Integrating bulk and single-cell data to predict the prognosis and identify the immune landscape in HNSCC.

ABSTRACT: The complex interplay between tumour cells and the tumour microenvironment (TME) underscores the necessity for gaining comprehensive insights into disease progression. This study centres on elucidating the elusive the elusive role of endothelial cells within the TME of head and neck squamous cell carcinoma (HNSCC). Despite their crucial involvement in angiogenesis and vascular function, the mechanistic diversity of endothelial cells among HNSCC patients remains largely uncharted. Leveraging advanced single-cell RNA sequencing (scRNA-Seq) technology and the Scissor algorithm, we aimed to bridge this knowledge gap and illuminate the intricate interplay between endothelial cells and patient prognosis within the context of HNSCC. Here, endothelial cells were categorized into Scissor^high</

SUBMITTER: Yang C 

PROVIDER: S-EPMC10805493 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature