Doxycycline Prophylaxis to Prevent Sexually Transmitted Infections in Women.

ABSTRACT:

Background

Doxycycline postexposure prophylaxis (PEP) has been shown to prevent sexually transmitted infections (STIs) among cisgender men and transgender women, but data from trials involving cisgender women are lacking.

Methods

We conducted a randomized, open-label trial comparing doxycycline PEP (doxycycline hyclate, 200 mg taken within 72 hours after condomless sex) with standard care among Kenyan women 18 to 30 years of age who were receiving preexposure prophylaxis against human immunodeficiency virus (HIV). The primary end point was any incident infection with Chlamydia trachomatis, Neisseria gonorrhoeae, or Treponema pallidum. Hair samples were collected quarterly for objective assessment of doxycycline use.

Results

A total of 449 particip

SUBMITTER: Stewart J 

PROVIDER: S-EPMC10805625 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature