Plasmon resonance biosensor for interleukin-1β point-of-care determination: A tool for early periodontitis diagnosis.

ABSTRACT: Among pro-inflammatory cytokines, Interleukin-1β is crucially involved in several inflammatory-based diseases and even cancer. Increased Interleukin-1β levels in oral fluids have been proposed as an early marker of periodontitis, a broadly diffused chronic inflammatory condition of periodontal-supporting tissues, leading eventually to tooth loss. We describe the development of a portable surface-plasmon-resonance-based optical fiber probe suitably coated with an anti-Interleukin-1β antibody monolayer. A pico-nanomolar linear range of determination was obtained in both buffer solution and saliva with a rapid (3 min) incubation and high selectivity in presence of interferents. Higher Interleukin-1β concentration in the saliva of a periodontitis patient compared to a healthy control was deter

SUBMITTER: Cennamo N 

PROVIDER: S-EPMC10805648 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature