Association of clinicopathologic and molecular factors with the occurrence of positive margins in breast cancer.

ABSTRACT:

Purpose

To explore the association of clinicopathologic and molecular factors with the occurrence of positive margins after first surgery in breast cancer.

Methods

The clinical and RNA-Seq data for 951 (75 positive and 876 negative margins) primary breast cancer patients from The Cancer Genome Atlas (TCGA) were used. The role of each clinicopathologic factor for margin prediction and also their impact on survival were evaluated using logistic regression, Fisher's exact test, and Cox proportional hazards regression models. In addition, differential expression analysis on a matched dataset (71 positive and 71 negative margins) was performed using Deseq2 and LASSO regression.

Results

Association studies showed that higher stage, larger tumor size (T), positive lymph node

SUBMITTER: Praveen Kumar A 

PROVIDER: S-EPMC10805852 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature