Exosomal secreted SCIMP regulates communication between macrophages and neutrophils in pneumonia.

ABSTRACT: In pneumonia, the deficient or delayed pathogen clearance can lead to pathogen proliferation and subsequent overactive immune responses, inducing acute lung injury (ALI). While screening human genome coding genes using our peripheral blood cell chemotactic platform, we unexpectedly find SLP adaptor and CSK interacting membrane protein (SCIMP), a protein with neutrophil chemotactic activity secreted during ALI. However, the specific role of SCIMP in ALI remains unclear. In this study, we investigate the secretion of SCIMP in exosomes (SCIMP^exo) by macrophages after bacterial stimulation, both in vitro and in vivo. We observe a significant increase in the levels of SCIMP^exo in bronchoalveolar lavage fluid and serum of pneumonia patients. We also find that bronchial perf

SUBMITTER: Pei X 

PROVIDER: S-EPMC10805922 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature