Molecular profiling of high-level athlete skeletal muscle after acute endurance or resistance exercise - A systems biology approach.

ABSTRACT:

Objective

Long-term high-level exercise training leads to improvements in physical performance and multi-tissue adaptation following changes in molecular pathways. While skeletal muscle baseline differences between exercise-trained and untrained individuals have been previously investigated, it remains unclear how training history influences human multi-omics responses to acute exercise.

Methods

We recruited and extensively characterized 24 individuals categorized as endurance athletes with >15 years of training history, strength athletes or control subjects. Timeseries skeletal muscle biopsies were taken from M. vastus lateralis at three time-points after endurance or resistance exercise was performed and multi-omics molecular analysis performed.

Results

Our analyses

SUBMITTER: Reitzner SM 

PROVIDER: S-EPMC10805945 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature