Anakinra-Associated Systemic Amyloidosis.

ABSTRACT:

Objective

To describe a 41-year-old woman with a history of neonatal onset multisystem inflammatory disease, on treatment with daily subcutaneous injections of 600 mg of recombinant interleukin-1 receptor antagonist (IL-1Ra) protein, anakinra, since the age of 28, who presented with golf-ball size nodules at the anakinra injection sites, early satiety, new onset nephrotic syndrome in the context of normal markers of systemic inflammation.

Methods

Clinical history and histologic evaluation of biopsies of skin, gastric mucosa, and kidney with Congo-red staining and proteomic evaluation of microdissected Congo red-positive amyloid deposits by liquid chromatography-tandem mass spectrometry.

Results

The skin, stomach, and kidney biopsies all showed the presence of Congo re

SUBMITTER: Alehashemi S 

PROVIDER: S-EPMC10805950 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature