Clinicopathologic and genetic analysis of invasive breast carcinomas in women with germline CHEK2 variants.

ABSTRACT:

Purpose

Germline pathogenic variants in checkpoint kinase 2 (CHEK2) are associated with a moderately increased risk of breast cancer (BC). The spectrum of clinicopathologic features and genetics of these tumors has not been fully established.

Methods

We characterized the histopathologic and clinicopathologic features of 44 CHEK2-associated BCs from 35 women, and assessed responses to neoadjuvant chemotherapy. A subset of cases (n = 23) was additionally analyzed using targeted next-generation DNA sequencing (NGS).

Results

Most (94%, 33/35) patients were heterozygous carriers for germline CHEK2 variants, and 40% had the c.1100delC allele. Two patients were homozygous, and five had additional germline pathogenic variants in ATM (2), PALB2 (1), RAD50 (1), or MUTYH (1). CH

SUBMITTER: Schwartz CJ 

PROVIDER: S-EPMC10806021 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature