Schizophrenia endothelial cells exhibit higher permeability and altered angiogenesis patterns in patient-derived organoids.

ABSTRACT: Schizophrenia (SCZ) is a complex neurodevelopmental disorder characterized by the manifestation of psychiatric symptoms in early adulthood. While many research avenues into the origins of SCZ during brain development have been explored, the contribution of endothelial/vascular dysfunction to the disease remains largely elusive. To model the neuropathology of SCZ during early critical periods of brain development, we utilized patient-derived induced pluripotent stem cells (iPSCs) to generate 3D cerebral organoids and define cell-specific signatures of disease. Single-cell RNA sequencing revealed that while SCZ organoids were similar in their macromolecular diversity to organoids generated from healthy controls (CTRL), SCZ organoids exhibited a higher percentage of endothelial cells when nor

SUBMITTER: Stankovic I 

PROVIDER: S-EPMC10806043 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature