Antigen-presenting B cells promote TCF-1⁺ PD1^- stem-like CD8⁺ T-cell proliferation in glioblastoma.

ABSTRACT: Understanding the spatial relationship and functional interaction of immune cells in glioblastoma (GBM) is critical for developing new therapeutics that overcome the highly immunosuppressive tumor microenvironment. Our study showed that B and T cells form clusters within the GBM microenvironment within a 15-μm radius, suggesting that B and T cells could form immune synapses within the GBM. However, GBM-infiltrating B cells suppress the activation of CD8⁺ T cells. To overcome this immunosuppression, we leveraged B-cell functions by activating them with CD40 agonism, IFNγ, and BAFF to generate a potent antigen-presenting B cells named B_Vax. B_Vax had improved antigen cross-presentation potential compared to naïve B cells and were primed to use the IL15-IL15Ra

SUBMITTER: Hou D 

PROVIDER: S-EPMC10806106 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature