Reduced mitochondrial respiration in peripheral T cells after paediatric heamatopoietic stem cell transplantation.

ABSTRACT:

Background

Recovery and functional differentiation of T-cell subsets are central for the development of immune function and complications after allogeneic hematopoietic stem cell transplantation (HSCT), but little is known about the cellular respiration and factors influencing T-cell metabolic fitness during immune maturation after HSCT.

Method

We included 20 HSCT patients and analysed mitochondrial oxidative phosphorylation and mitochondrial fitness in peripheral blood mononuclear cell samples collected at days +90 and +180 after HSCT.

Results

Phenotypic analysis revealed lower overall T-cell counts, lower CD4+/CD8+ ratio and a skewed distribution of early T-cell subsets at day +90, gradually recovering by day +180. Although ATP turnover in HSCT patients was similar

SUBMITTER: Molgaard K 

PROVIDER: S-EPMC10806108 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature