Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity.

ABSTRACT: Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis, which is characterized by increased bone resorption and inadequate bone formation. As novel antiosteoporotic therapeutics are needed, understanding the genetic regulation of human osteoclastogenesis could help identify potential treatment targets. This study aimed to provide an overview of transcriptional reprogramming during human osteoclast differentiation. Osteoclasts were differentiated from CD14⁺ monocytes from eight female donors. RNA sequencing during differentiation revealed 8 980 differentially expressed genes grouped into eight temporal patterns conserved across donors. These patterns revealed distinct molecular functions associated with postmenopausal osteoporosis suscep

SUBMITTER: Hansen MS 

PROVIDER: S-EPMC10806178 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature