Interferon response and profiling of interferon response genes in peripheral blood of vaccine-naive COVID-19 patients.

ABSTRACT:

Introduction

There is insufficient understanding on systemic interferon (IFN) responses during COVID-19 infection. Early reports indicated that interferon responses were suppressed by the coronavirus (SARS-CoV-2) and clinical trials of administration of various kinds of interferons had been disappointing. Expression of interferon-stimulated genes (ISGs) in peripheral blood (better known as interferon score) has been a well-established bioassay marker of systemic IFN responses in autoimmune diseases. Therefore, with archival samples of a cohort of COVID-19 patients collected before the availability of vaccination, we aimed to better understand this innate immune response by studying the IFN score and related ISGs expression in bulk and single cell RNAs sequencing expression datasets

SUBMITTER: Huang B 

PROVIDER: S-EPMC10806211 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature