Persistence of KIR^neg NK cells after haploidentical hematopoietic stem cell transplantation protects from human cytomegalovirus infection/reactivation.

ABSTRACT: Haploidentical hematopoietic stem cell transplantation (h-HSCT) is a therapeutic option to cure patients affected by hematologic malignancies. The kinetics and the quality of immune-reconstitution (IR) impact the clinical outcome of h-HSCT and limit the onset of life-threatening Human Cytomegalovirus (HCMV) infection/reactivation. Natural Killer (NK) cells are the first lymphocytes that recover after h-HSCT and they can provide rapid innate immune responses against opportunistic pathogens. By performing a longitudinal single-cell analysis of multiparametric flow-cytometry data, we show here that the persistence at high frequencies of CD158b1b2j^neg/NKG2A^pos/NKG2C^neg/NKp30^pos/NKp46^pos (KIR^neg) NK cells is associated with HCMV

SUBMITTER: Di Vito C 

PROVIDER: S-EPMC10806243 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature