Integrated analysis of RNA-seq datasets reveals novel targets and regulators of COVID-19 severity.

ABSTRACT: During the COVID-19 pandemic, RNA-seq datasets were produced to investigate the virus-host relationship. However, much of these data remains underexplored. To improve the search for molecular targets and biomarkers, we performed an integrated analysis of multiple RNA-seq datasets, expanding the cohort and including patients from different countries, encompassing severe and mild COVID-19 patients. Our analysis revealed that severe COVID-19 patients exhibit overexpression of genes coding for proteins of extracellular exosomes, endomembrane system, and neutrophil granules (e.g., S100A9, LY96, and RAB1B), which may play an essential role in the cellular response to infection. Concurrently, these patients exhibit down-regulation of genes encoding components of the T cell re

SUBMITTER: Oliveira TT 

PROVIDER: S-EPMC10806258 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature