Diurnal production of cortisol and prediction of treatment response in rheumatoid arthritis: a 6-month, real-life prospective cohort study.

ABSTRACT:

Objectives

A reduced adrenal reserve-associated cortisol production relative to the enhanced needs of chronic inflammation (disproportion principle) has been observed in rheumatoid arthritis (RA). We examined the possible clinical value of diurnal cortisol measurements in active RA on treatment response prediction.

Methods

Diurnal cortisol production (measured at: 08-12:00/18:00-22:00) was assessed by electrochemiluminescence immunoassay in 28 consecutive patients with moderately/highly active RA, as well as 3 and 6 months after treatment initiation or/escalation. Twenty-eight COVID-19 patients and 28 age-matched healthy individuals (HC) served as controls.

Results

Saliva diurnal cortisol production in patients with RA was similar to that of HC, despite 12-fold

SUBMITTER: Yavropoulou MP 

PROVIDER: S-EPMC10806498 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature