Effects of a periodic intermittent theta burst stimulation in Alzheimer's disease.

ABSTRACT:

Background

Previous studies have demonstrated that excitatory repetitive transcranial magnetic stimulation (rTMS) can improve the cognitive function of patients with Alzheimer's disease (AD). Intermittent theta burst stimulation (iTBS) is a novel excitatory rTMS protocol for brain activity stimulation with the ability to induce long-term potentiation-like plasticity and represents a promising treatment for AD. However, the long-term effects of iTBS on cognitive decline and brain structure in patients with AD are unknown.

Aims

We aimed to explore whether repeating accelerated iTBS every three months could slow down the cognitive decline in patients with AD.

Methods

In this randomised, assessor-blinded, controlled trial, iTBS was administered to the left dorsolateral pr

SUBMITTER: Wu X 

PROVIDER: S-EPMC10806514 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature