Normal saline for children with bronchiolitis: study protocol for a randomised controlled non-inferiority trial.

ABSTRACT:

Introduction

Bronchiolitis is one of the most common reasons for hospital admissions in early childhood. As supportive treatment, some treatment guidelines suggest using nasal irrigation with normal saline (NS) to facilitate clearance of mucus from the airways. In addition, most paediatric departments in Denmark use nebulised NS for the same purpose, which can mainly be administered as inpatient care. However, no studies have ever directly tested the effect of saline in children with bronchiolitis.

Methods and analysis

The study is an investigator-initiated, multicentre, open-label, randomised, controlled non-inferiority trial and will be performed at six paediatric departments in eastern Denmark. We plan to include 300 children aged 0-12 months admitted to hospital with bro

SUBMITTER: Schmidt MN 

PROVIDER: S-EPMC10806597 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature