PD-1/PD-L1 governed cross-talk of exhausted CD8⁺ T and memory B cells in systemic lupus erythematosus.

ABSTRACT:

Background

Indeterminate readout of the quantitative interferon-γ release test (QFT) for Mycobacterium tuberculosis screening is a specific laboratory finding for systemic lupus erythematosus (SLE), which may be due to T-cell exhaustion and abnormal programmed death receptor 1 (PD-1)/programmed death-ligand 1 (PD-L1) signalling.

Methods

We enrolled 104 patients with SLE and 225 with other rheumatic musculoskeletal diseases (RMDs) who presented to the outpatient clinic between 2020 and 2023. Twenty healthy donors served as the controls. The QFT was performed in all participants, and those with indeterminate results were compared among the groups. Immunophenotyping and functional assays were performed using blood mononuclear cells. Interferon (IFN)-γ was detected in vit

SUBMITTER: Wang K 

PROVIDER: S-EPMC10806639 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature