Chemometric sensing of stereoisomeric compound mixtures with a redox-responsive optical probe.

ABSTRACT: The analysis of mixtures of chiral compounds is a common task in academic and industrial laboratories typically achieved by laborious and time-consuming physical separation of the individual stereoisomers to allow interference-free quantification, for example using chiral chromatography coupled with UV detection. Current practice thus impedes high-throughput and slows down progress in countless chiral compound development projects. Here we describe a chemometric solution to this problem using a redox-responsive naphthoquinone that enables chromatography-free click chemistry sensing of challenging mixtures. The achiral probe covalently binds amino alcohols within a few minutes at room temperature and generates characteristic UV_A and CD_A spectra that are intentionally a

SUBMITTER: Formen JSSK 

PROVIDER: S-EPMC10806675 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature