OmicSynth: An open multi-omic community resource for identifying druggable targets across neurodegenerative diseases.

ABSTRACT: Treatments for neurodegenerative disorders remain rare, but recent FDA approvals, such as lecanemab and aducanumab for Alzheimer disease (MIM: 607822), highlight the importance of the underlying biological mechanisms in driving discovery and creating disease modifying therapies. The global population is aging, driving an urgent need for therapeutics that stop disease progression and eliminate symptoms. In this study, we create an open framework and resource for evidence-based identification of therapeutic targets for neurodegenerative disease. We use summary-data-based Mendelian randomization to identify genetic targets for drug discovery and repurposing. In parallel, we provide mechanistic insights into disease processes and potential network-level consequences of gene-based therapeutics.

SUBMITTER: Alvarado CX 

PROVIDER: S-EPMC10806756 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature